As far as eliminating the vacuum accessories is concerned, the easiest one is to get rid of the "cruise control." It is a little gray box that mounts somewhere near the driver's side wheel-well. I got rid of mine all together because it functioned by just holding the throttle in a constant position (so it really didn't do anything for maintaining speed up or down hills). Good idea for the 60's, but I don't mind keeping my foot on the throttle. If you eliminate this box and retain your factory speedo, you will however have to get a new speedometer cable because the fittings don't match up. If you haven't eliminated the entire vacuum system, then cap off/plug the port that connected with vacuum.
I also eliminated the vacuum door locks...I don't mind turning a key. Follow the vacuum lines through the door and again disconnect and plug off where they meet up to the greater vacuum control. If you convert to the electric headlights, https://www.ebay.com/itm/322444352271?rmvSB=true
(they are a little pricy) and convert to electric, you also eliminate that portion of the vacuum connect, leaving only the heating/AC system and brake booster to draw vacuum. My plan is to install an under the dash heating/defrost/vent system (you could do A/C if you want, but I don't want the power draw or weight) from these guys https://www.vintageair.com/
If you run an under the dash unit you can eliminate the foolishness in having to ever change out the blower fan (not sure if you have had that joy or not yet, but you have to take off the hood, hood mount, and basically the entire A/C system which is really a pain to reach the bottom few bolts. My car happens to have rusted through on the firewall just below the ducting to the heater core, so I plan on welding a flat sheet of steel to patch the hole, seal off existing ducting holes, and generally smooth out the firewall. If you go with an under the dash system, you can basically eliminate all the need for vacuum inside the cabin. It is a bit of a project (and I haven't undertaken it yet, but I've fought the heating/ventilation system enough that I needed to reengineer it). Plus, vintage air makes some nice control panels that look pretty professional. As long as you aren't afraid of some simple wiring, it really modernizes the car.
Finally, I should let you know about the windshield wiper dilemma. Ford, in all of its infinite wisdom decided to run a hydraulic windshield wiper setup. If the thing fails, it usually seizes open and keeps the windshield wipers on. It happened to me. So i've ben looking for an electric conversion. No one makes one yet...but I have been communicating with https://newportwipers.com/
and they are trying to build a solution for Lincolns/Thunderbirds. Converting to electric would declutter the engine bay, eliminate those ugly hydraulic hoses, and hopefully give some more clearance for headers. Anyway, hopefully some of this is useful.