Beginning a tune is more involved than first thought, but the foundation is set well here. Most important is to get your system settings right (inputs, outputs, calibrations, etc) sitting at your desk with cups of coffee.…This is still my stock 460 at this point. If so, how you you recommend running it? note, I haven't installed this yet. Just getting things ready. from my understanding I'd want to start bringing in more fuel around 65kpa than is shown here.
Next, base tunes are sometimes purposely inaccurate, but have values to simply hold the place, in order to prevent tune corruption (no value = the ECM gets confused). So, don't take any default values as necessarily significant to your setup. An example could be the legendary 14.7:1, which is a reference point (stoichiometric or Lambda 1.0), but not good for either power or economy. It is rarely used in real-world tunes except for emissions regulations.
Technically, you do not ever tune to an AFR. I know, that's a common belief, but it's backwards. You test and tune to find the best AFR to use at that speed and load, and then you use it as a target.
After first start and warmup, you logically step through initial tuning of idle for both most efficient fuel and best timing. Then set your warm startup settings for best restarts (later cold startup and warmup are based on the tuned table and warm start settings). Then begin working on the off-idle areas, in order to find best performance by engine feedback. Note at no time are we tuning to an AFR, but rather to best engine operation from logs and feedback.
Once we are done with a tuning phase, e.g., idle, we can then read the AFRs produced with best running. Now we have good AFR targets to use in our corrections table like the one you posted.
This can all get very deep as you move from basic to advanced tuning, and I'll see about shooting you some good references of proven methods for street-tuners (same as dyno tuners, but different parameters and methods). You can do this!
PS: Where on the planet does your generally truck live?