2 bolt
I built a 557 a few years ago for Flow Technologies to demonstrate the horsepower capabilities of their cylinder head on a very basic short block. It was a 2 bolt D1VE block with studs and a halo, Scat 9000 series 4.500 stroke crank, Eagle 6.700 rods, JE pistons, very basic stuff. That engine made 902 horsepower at 7000rpm on my dyno running on racing gasoline with one Dominator carburetor.
Later the engine was run in a dragster and sometimes they would run a 100 horsepower shot of nitrous for part of the run. It ran a best of 7.38 1/4 mile with a 1.06 60ft time and it was very very consistent. Anyway, the crankshaft was the weak link in the engine and it broke in the back rod throw after about 75 passes in the dragster, 15 dyno pulls and about 5 test passes in Wes' car.
When the engine was taken apart it was a mess of course but the main bearings and caps looked fine, as did the rod bearings, cylinder walls etc. The block wasn't any worse for wear and if the crank had not failed it would have lived just fine.
I do feel that this was pushing it, by a long shot however I do feel that if you're making around 800 horsepower the two bolt block can live just fine without problems, same goes for the Scat cast cranks, I think they would live a very long time at that power level, given the proper tuneup of course...