Xoliex, you don't want to gundrill your axles. They do gundrilling for axles from least 35-40 splines (not sure do they drill 33 splines). According Moser Engineering gundrilling makes the axle 30 % weaker but ofcourse lighter. I have 35 splines moser's rated app. 1100hp. Gundrilling those would lower the rating to app. 850 hp, in a street car I don't see much sense in gundrillig - why pay extra to make them weaker??? I understand it in hardcore racing where you can save some weight but not for street.
I have used detroitlocker with 28 splines and with 35 splines axles, no issues ever. You cant though open the throttle in corner but who would when you've got some hp on your rearwheels. I've got a basic Ford Motorsport based M-6009-C460 crate engine, dissassembled, balanced and blueprinted with A429 heads, G-429 victor, C460 flattappet. Has not been in dyno here locally, but according the weight of the vehicle (3790 lbs with driver) and 1/4 mile trapspeed 118mph, I've got app. 500hp on rear wheels. 4.11 gears and TKO600 with 0,64 overdrive, gets the car to 15 mpg on highway with 60mph, if driving like a granny I can make it to the 16 mpg at 60mph.
If you're not sure from the TKO600 capabilities you can allways get one from MMR or from American Powertrain, they do modify TKO:s to handle more hp/torque. Stock TKO600 should handle a pinch over 700 lb ft, or at least it's what we have seen them to handle with slicks without issues in a 3600lbs car.
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edit:
I forgot to mention that with 500hp rearwheel power you don't need 35 splines axles, but it gives you a room for growth in future. That's exactly why I choose the 35 splines, since updating from 28 splines to 31 splines would have costed me the same.